Endocrine Abstracts

Pancreatic beta cell dysfunction is central to the development and progression of type 2 diabetes (T2D). Lipotoxicity, i.e. chronic exposure to elevated levels of free fatty acids (FFAs), contributes to beta cell dysfunction and death in T2D.The endoplasmic reticulum (ER) is the organelle where secreted proteins, such as insulin, are produced and folded. Demands placed on the beta cell ER vary greatly with glucose-stimulated insulin production. ER stress...